Recent Publications from BIIC Members

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You are hereRecent Publications of Members of the Boston Ithaca Islet Club

Recent Publications of Members of the Boston Ithaca Islet Club

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2012
Smrcka AV, Brown JH, Holz GG.  2012.  Role of phospholipase Cε in physiological phosphoinositide signaling networks.. Cellular Signalling.
2011
Leech CA, Dzhura I, Chepurny OG, Kang G, Schwede F, Genieser H, Holz GG.  2011.  Molecular physiology of glucagon-like peptide-1 insulin secretagogue action in pancreatic beta cells.. Progress in Biophysics and Molecular Biology. 107:236-247.
Dzhura I, Chepurny OG, Leech CA, Roe MW, Dzhura E, Xu X, Lu Y, Schwede F, Genieser H, Smrcka AV, Holz GG.  2011.  Phospholipase C-ε links Epac2 activation to the potentiation of glucose-stimulated insulin secretion from mouse islets of Langerhans. Islets. 3:3 Abstract
Dzhura I, Chepurny OG, Leech CA, Roe MW, Dzhura E, Xu X, Lu Y, Schwede F, Genieser H, Smrcka AV, Holz GG.  2011.  Phospholipase C-epsilon links Epac2 activation to islet insulin secretion. Islets. 3:1-8.
2010
Leech CA, Chepurny OG, Holz GG.  2010.  Epac2-dependent rap1 activation and the control of islet insulin secretion by glucagon-like peptide-1. . Vitamins and Hormones. 84:279-302. Abstract
Dzhura I, Chepurny OG, Kelley GG, Leech CA, Roe MW, Dzhura E, Afshari P, Malik S, Rindler MJ, Xu X, Lu Y, Smrcka AV, Holz GG.  2010.  Epac2-dependent mobilization of intracellular Ca2+ by glucagon-like peptide-1 receptor agonist exendin-4 is disrupted in beta-cells of phospholipase C-epsilon knockout mice.. The Journal of Physiology. 588:4871-4889. Abstract
Leech CA, Dzhura I, Chepurny OG, Schwede F, Genieser HG, Holz GG.  2010.  Facilitation of ß-cell K-ATP channel sulfonylurea sensitivity by a cAMP analog selective for the cAMP-regulated guanine nucleotide exchange factor Epac.. Islets. 2:72-81. Abstract
Chepurny OG, Kelley GG, Dzhura I, Leech CA, Roe MW, Dzhura E, Li X, Schwede F, Genieser HG, Holz GG.  2010.  PKA-dependent potentiation of glucose-stimulated insulin secretion by Epac activator 8-pCPT-2'-O-Me-cAMP-AM in human islets of Langerhans.. Am J Physiol Endocrinol Metab. 298:E622-633. Abstract
Gray JP, Heart E.  2010.  Usurping the mitochondrial supremacy: extramitochondrial sources of reactive oxygen intermediates and their role in beta cell metabolism and insulin secretion. Toxicol Mech Methods. 20:167-174. Abstract
2009
Guay C, Goudreault D, Schanzer W, Flenker U, Ayotte C.  2009.  Excretion of norsteroids' phase II metabolites of different origin in human. Steroids. 74(3):350-8. Abstract
Torii S, Saito N, Kawano A, Hou N, Ueki K, Kulkarni RN, Takeuchi T.  2009.  Gene silencing of phogrin unveils its essential role in glucose-responsive pancreatic beta-cell growth. Diabetes. 58(3):682-92. Abstract
Pi J, Zhang Q, Fu J, Woods CG, Hou Y, Corkey BE, Collins S, Andersen ME.  2009.  ROS signaling, oxidative stress and Nrf2 in pancreatic beta-cell function. Toxicol Appl Pharmacol. Abstract
Wikstrom JD, Twig G, Shirihai OS.  2009.  What can mitochondrial heterogeneity tell us about mitochondrial dynamics and autophagy? Int J Biochem Cell Biol. Abstract
Peyot ML, Guay C, Latour MG, Lamontagne J, Lussier R, Pineda M, Ruderman NB, Haemmerle G, Zechner R, Joly E, Madiraju SR, Poitout V, Prentki M.  2009.  Adipose triglyceride lipase is implicated in fuel- and non-fuel-stimulated insulin secretion. J Biol Chem. 284(25):16848-59. Abstract
Harbilas D, Martineau LC, Harris CS, Adeyiwola-Spoor DC, Saleem A, Lambert J, Caves D, Johns T, Prentki M, Cuerrier A, Arnason JT, Bennett SA, Haddad PS.  2009.  Evaluation of the antidiabetic potential of selected medicinal plant extracts from the Canadian boreal forest used to treat symptoms of diabetes: part II. Can J Physiol Pharmacol. 87(6):479-92. Abstract
Assmann A, Ueki K, Winnay JN, Kadowaki T, Kulkarni RN.  2009.  Glucose effects on beta-cell growth and survival require activation of insulin receptors and insulin receptor substrate 2. Mol Cell Biol. 29(11):3219-28. Abstract
Delghingaro-Augusto V, Nolan CJ, Gupta D, Jetton TL, Latour MG, Peshavaria M, Madiraju SR, Joly E, Peyot ML, Prentki M, Leahy J.  2009.  Islet beta cell failure in the 60% pancreatectomised obese hyperlipidaemic Zucker fatty rat: severe dysfunction with altered glycerolipid metabolism without steatosis or a falling beta cell mass. Diabetologia. 52(6):1122-32. Abstract
Heart E, Cline GW, Collis LP, Pongratz RL, Gray JP, Smith PJ.  2009.  Role for malic enzyme, pyruvate carboxylation, and mitochondrial malate import in glucose-stimulated insulin secretion. Am J Physiol Endocrinol Metab. 296(6):E1354-62. Abstract
Bendayan M, Londono I, Kemp B, Hardie GD, Ruderman N, Prentki M.  2009.  Association of AMP-activated Protein Kinase Subunits With Glycogen Particles as Revealed In Situ by Immuno-electron Microscopy. J Histochem Cytochem. Abstract
Getty-Kaushik L, Richard AM, Deeney JT, Krawczyk S, Shirihai O, Corkey BE.  2009.  The CB1 Antagonist Rimonabant Decreases Insulin Hypersecretion in Rat Pancreatic Islets. Obesity (Silver Spring). Abstract
Molina AJ, Wikstrom JD, Stiles L, Las G, Mohamed H, Elorza A, Walzer G, Twig G, Katz S, Corkey BE, Shirihai OS.  2009.  Mitochondrial Networking Protects Beta Cells from Nutrient Induced Apoptosis. Diabetes. Abstract
Pi J, Bai Y, Daniel KW, Liu D, Lyght O, Edelstein D, Brownlee M, Corkey BE, Collins S.  2009.  Persistent oxidative stress due to absence of uncoupling protein 2 associated with impaired pancreatic beta-cell function. Endocrinology. 150(7):3040-8. Abstract
Kulkarni RN.  2009.  Uncoupling modifier genes from uncoupling protein 2 in pancreatic beta-cells. Endocrinology. 150(7):2994-6.
Guo S, Burnette R, Zhao L, Vanderford NL, Poitout V, Hagman DK, Henderson E, Ozcan S, Wadzinski BE, Stein R.  2009.  The stability and transactivation potential of the mammalian MafA transcription factor are regulated by serine 65 phosphorylation. J Biol Chem. 284(2):759-65. Abstract
Emamaullee JA, Merani S, Toso C, Kin T, Al-Saif F, Truong W, Pawlick R, Davis J, Edgar R, Lock J, Bonner-Weir S, Knudsen LB, Shapiro AM.  2009.  Porcine marginal mass islet autografts resist metabolic failure over time and are enhanced by early treatment with liraglutide. Endocrinology. Abstract

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