Recent Publications from BIIC Members

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You are hereRecent Publications of Members of the Boston Ithaca Islet Club

Recent Publications of Members of the Boston Ithaca Islet Club

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Filters: Author is Holz, G. G.  [Clear All Filters]
2010
Leech CA, Chepurny OG, Holz GG.  2010.  Epac2-dependent rap1 activation and the control of islet insulin secretion by glucagon-like peptide-1. . Vitamins and Hormones. 84:279-302. Abstract
Dzhura I, Chepurny OG, Kelley GG, Leech CA, Roe MW, Dzhura E, Afshari P, Malik S, Rindler MJ, Xu X, Lu Y, Smrcka AV, Holz GG.  2010.  Epac2-dependent mobilization of intracellular Ca2+ by glucagon-like peptide-1 receptor agonist exendin-4 is disrupted in beta-cells of phospholipase C-epsilon knockout mice.. The Journal of Physiology. 588:4871-4889. Abstract
Leech CA, Dzhura I, Chepurny OG, Schwede F, Genieser HG, Holz GG.  2010.  Facilitation of ß-cell K-ATP channel sulfonylurea sensitivity by a cAMP analog selective for the cAMP-regulated guanine nucleotide exchange factor Epac.. Islets. 2:72-81. Abstract
Chepurny OG, Kelley GG, Dzhura I, Leech CA, Roe MW, Dzhura E, Li X, Schwede F, Genieser HG, Holz GG.  2010.  PKA-dependent potentiation of glucose-stimulated insulin secretion by Epac activator 8-pCPT-2'-O-Me-cAMP-AM in human islets of Langerhans.. Am J Physiol Endocrinol Metab. 298:E622-633. Abstract
2009
Chepurny OG, Leech CA, Kelley GG, Dzhura I, Dzhura E, Li X, Rindler MJ, Schwede F, Genieser HG, Holz GG.  2009.  Enhanced Rap1 activation and insulin secretagogue properties of an acetoxymethyl ester of an Epac-selective cyclic AMP analog in rat INS-1 cells: studies with 8-pCPT-2'-O-Me-cAMP-AM. J Biol Chem. 284(16):10728-36. Abstract
Kelley GG, Chepurny OG, Schwede F, Genieser HG, Leech CA, Roe MW, Li X, Dzhura I, Dzhura E, Afshari P, Holz GG.  2009.  Glucose-dependent potentiation of mouse islet insulin secretion by Epac activator 8-pCPT-2'-O-Me-cAMP-AM. Islets. 1(3):1-6. Abstract
Leech CA, Dzhura I, Chepurny OG, Schwede F, Genieser H-G, Holz GG.  2009.  Facilitation of β-cell KATP channel sulfonylurea sensitivity by a cAMP analog selective for the cAMP-regulated guanine nucleotide exchange factor Epac. Islets. 2 Abstract
Peyot ML, Gray JP, Lamontagne J, Smith PJ, Holz GG, Madiraju SR, Prentki M, Heart E.  2009.  Glucagon-like peptide-1 induced signaling and insulin secretion do not drive fuel and energy metabolism in primary rodent pancreatic beta-cells. PLoS One. 4(7):e6221. Abstract
2008
Kang G, Leech CA, Chepurny OG, Coetzee WA, Holz GG.  2008.  Role of the cAMP sensor Epac as a determinant of KATP channel ATP sensitivity in human pancreatic beta-cells and rat INS-1 cells. J Physiol. 586(5):1307-19. Abstract
Holz GG, Chepurny OG, Schwede F.  2008.  Epac-selective cAMP analogs: new tools with which to evaluate the signal transduction properties of cAMP-regulated guanine nucleotide exchange factors. Cell Signal. 20(1):10-20. Abstract
Holz GG, Heart E, Leech CA.  2008.  Synchronizing Ca2+ and cAMP oscillations in pancreatic beta-cells: a role for glucose metabolism and GLP-1 receptors? Focus on "regulation of cAMP dynamics by Ca2+ and G protein-coupled receptors in the pancreatic beta-cell: a computational approach" Am J Physiol Cell Physiol. 294(1):C4-6.
Stanojevic V, Habener JF, Holz GG, Leech CA.  2008.  Cytosolic adenylate kinases regulate K-ATP channel activity in human beta-cells. Biochem Biophys Res Commun. 368(3):614-9. Abstract
2007
Chepurny OG, Holz GG.  2007.  A novel cyclic adenosine monophosphate responsive luciferase reporter incorporating a nonpalindromic cyclic adenosine monophosphate response element provides optimal performance for use in G protein coupled receptor drug discovery efforts. J Biomol Screen. 12(5):740-6. Abstract
2006
Harbeck MC, Chepurny O, Nikolaev VO, Lohse MJ, Holz GG, Roe MW.  2006.  Simultaneous optical measurements of cytosolic Ca2+ and cAMP in single cells. Sci STKE. 2006(353):pl6. Abstract
Holz GG, Kang G, Harbeck M, Roe MW, Chepurny OG.  2006.  Cell physiology of cAMP sensor Epac. J Physiol. 577(Pt 1):5-15. Abstract
Kang G, Chepurny OG, Malester B, Rindler MJ, Rehmann H, Bos JL, Schwede F, Coetzee WA, Holz GG.  2006.  cAMP sensor Epac as a determinant of ATP-sensitive potassium channel activity in human pancreatic beta cells and rat INS-1 cells. J Physiol. 573(Pt 3):595-609. Abstract
2005
Landa L. R. J, Harbeck M, Kaihara K, Chepurny O, Kitiphongspattana K, Graf O, Nikolaev VO, Lohse MJ, Holz GG, Roe MW.  2005.  Interplay of Ca2+ and cAMP signaling in the insulin-secreting MIN6 beta-cell line. J Biol Chem. 280(35):31294-302. Abstract
Kang G, Chepurny OG, Rindler MJ, Collis L, Chepurny Z, Li WH, Harbeck M, Roe MW, Holz GG.  2005.  A cAMP and Ca2+ coincidence detector in support of Ca2+-induced Ca2+ release in mouse pancreatic beta cells. J Physiol. 566(Pt 1):173-88. Abstract
Holz GG, Chepurny OG.  2005.  Diabetes outfoxed by GLP-1? Sci STKE. 2005(268):pe2. Abstract

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