Recent Publications from BIIC Members

Pancreatic beta cell mass PET imaging and quantification with [11C]DTBZ and [18F]FP-(+)-DTBZ in rodent models of diabetes.
Role of phospholipase Cε in physiological phosphoinositide signaling networks.
Insulin augmentation of glucose-stimulated insulin secretion is impaired in insulin-resistant humans.
Reactive oxygen species stimulate insulin secretion in rat pancreatic islets: studies using mono-oleoyl-glycerol.
Epac2-dependent mobilization of intracellular Ca2+ by glucagon-like peptide-1 receptor agonist exendin-4 is disrupted in beta-cells of phospholipase C-epsilon knockout mice.
Hyperglucagonemia precedes a decline in insulin secretion and causes hyperglycemia in chronically glucose-infused rats.
Cytoplasmic Polyadenylation Element Binding Protein Deficiency Stimulates PTEN and Stat3 mRNA Translation and Induces Hepatic Insulin Resistance.
Prevalence of hepatitis C virus genotype 1a in Japan and correlation of mutations in the NS5A region and single-nucleotide polymorphism of interleukin-28B with the response to combination therapy with pegylated-interferon-alpha 2b and ribavirin.
Rates of insulin secretion in INS-1 cells are enhanced by coupling to anaplerosis and Kreb's cycle flux independent of ATP synthesis.
CT-PET weighted image fusion for separately scanned whole body rat.

You are hereRecent Publications of Members of the Boston Ithaca Islet Club

Recent Publications of Members of the Boston Ithaca Islet Club

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2010

Dzhura I, Chepurny OG, Kelley GG, Leech CA, Roe MW, Dzhura E, Afshari P, Malik S, Rindler MJ, Xu X, Lu Y, Smrcka AV, Holz GG. 2010. Epac2-dependent mobilization of intracellular Ca2+ by glucagon-like peptide-1 receptor agonist exendin-4 is disrupted in beta-cells of phospholipase C-epsilon knockout mice.. The Journal of Physiology. 588:4871-4889. Abstract

Chepurny OG, Kelley GG, Dzhura I, Leech CA, Roe MW, Dzhura E, Li X, Schwede F, Genieser HG, Holz GG. 2010. PKA-dependent potentiation of glucose-stimulated insulin secretion by Epac activator 8-pCPT-2'-O-Me-cAMP-AM in human islets of Langerhans.. Am J Physiol Endocrinol Metab. 298:E622-633. Abstract

2009

Kelley GG, Chepurny OG, Schwede F, Genieser HG, Leech CA, Roe MW, Li X, Dzhura I, Dzhura E, Afshari P, Holz GG. 2009. Glucose-dependent potentiation of mouse islet insulin secretion by Epac activator 8-pCPT-2'-O-Me-cAMP-AM. Islets. 1(3):1-6. Abstract

2006

Harbeck MC, Chepurny O, Nikolaev VO, Lohse MJ, Holz GG, Roe MW. 2006. Simultaneous optical measurements of cytosolic Ca2+ and cAMP in single cells. Sci STKE. 2006(353):pl6. Abstract

Holz GG, Kang G, Harbeck M, Roe MW, Chepurny OG. 2006. Cell physiology of cAMP sensor Epac. J Physiol. 577(Pt 1):5-15. Abstract

2005

Landa L. R. J, Harbeck M, Kaihara K, Chepurny O, Kitiphongspattana K, Graf O, Nikolaev VO, Lohse MJ, Holz GG, Roe MW. 2005. Interplay of Ca2+ and cAMP signaling in the insulin-secreting MIN6 beta-cell line. J Biol Chem. 280(35):31294-302. Abstract

Kang G, Chepurny OG, Rindler MJ, Collis L, Chepurny Z, Li WH, Harbeck M, Roe MW, Holz GG. 2005. A cAMP and Ca2+ coincidence detector in support of Ca2+-induced Ca2+ release in mouse pancreatic beta cells. J Physiol. 566(Pt 1):173-88. Abstract

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