31 Hinault, C. Hu, J. Maier, B. F. Mirmira, R. G. Kulkarni, R. N. 2008 Diabetes Obes Metab 10 Suppl 4 136-46 Nov 1463-1326 (Electronic) 18834441 Signal Transduction/physiology Pancreas, Exocrine/metabolism/*physiopathology Islets of Langerhans/metabolism/*physiology Humans Gene Expression Diabetes Mellitus, Type 2/metabolism/*physiopathology Cell Proliferation Cell Cycle Proteins/*physiology Animals Aging/physiology Diabetes Mellitus Pancreas Exocrine/metabolism/*physiopathology Type 2/metabolism/*physiopathology One of the major challenges for developmental biologists and investigators in the field of diabetes over the last few decades has been to dissect the origin of pancreatic endocrine cells and to accurately understand the mechanisms that regulate islet cell regeneration. While significant advances have been made recently, there continues to be a paucity of knowledge regarding the growth factor signalling pathways that directly regulate the proteins involved in islet cell cycle control. We will discuss recent work in these areas and provide insights from our studies into age-dependent alterations in the expression of growth factor signalling proteins and cell cycle proteins in islet cells. 1RL9EB008539-01/EB/NIBIB NIH HHS/United StatesR01 DK60581/DK/NIDDK NIH HHS/United StatesR01 DK67536/DK/NIDDK NIH HHS/United StatesJournal ArticleResearch Support, N.I.H., ExtramuralReviewEngland http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18834441