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Recent Publications of Members of the Boston Ithaca Islet Club


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2008
Choi CS, Befroy DE, Codella R, Kim S, Reznick RM, Hwang YJ, Liu ZX, Lee HY, Distefano A, Samuel VT, Zhang D, Cline GW, Handschin C, Lin J, Petersen KF, Spiegelman BM, Shulman GI.  2008.  Paradoxical effects of increased expression of PGC-1alpha on muscle mitochondrial function and insulin-stimulated muscle glucose metabolism. Proc Natl Acad Sci U S A. 105(50):19926-31. Abstract
2007
Choi CS, Savage DB, Abu-Elheiga L, Liu ZX, Kim S, Kulkarni A, Distefano A, Hwang YJ, Reznick RM, Codella R, Zhang D, Cline GW, Wakil SJ, Shulman GI.  2007.  Continuous fat oxidation in acetyl-CoA carboxylase 2 knockout mice increases total energy expenditure, reduces fat mass, and improves insulin sensitivity. Proc Natl Acad Sci U S A. 104(42):16480-5. Abstract
Kibbey RG, Pongratz RL, Romanelli AJ, Wollheim CB, Cline GW, Shulman GI.  2007.  Mitochondrial GTP regulates glucose-stimulated insulin secretion. Cell Metab. 5(4):253-64. Abstract
2006
Qi L, Heredia JE, Altarejos JY, Screaton R, Goebel N, Niessen S, Macleod IX, Liew CW, Kulkarni RN, Bain J, Newgard C, Nelson M, Evans RM, Yates J, Montminy M.  2006.  TRB3 links the E3 ubiquitin ligase COP1 to lipid metabolism. Science. 312(5781):1763-6. Abstract
Cline GW.  2006.  Tough love: left out in the cold, but not abandoned, by UCP3. J Appl Physiol. 101(1):12-3.
2005
Zang Y, Wang T, Xie W, Wang-Fischer YL, Getty L, Han J, Corkey BE, Guo W.  2005.  Regulation of acetyl CoA carboxylase and carnitine palmitoyl transferase-1 in rat adipocytes. Obes Res. 13(9):1530-9. Abstract
Hammond LE, Neschen S, Romanelli AJ, Cline GW, Ilkayeva OR, Shulman GI, Muoio DM, Coleman RA.  2005.  Mitochondrial glycerol-3-phosphate acyltransferase-1 is essential in liver for the metabolism of excess acyl-CoAs. J Biol Chem. 280(27):25629-36. Abstract
Carey PE, Gerrard J, Cline GW, Dalla Man C, English PT, Firbank MJ, Cobelli C, Taylor R.  2005.  Acute inhibition of lipolysis does not affect postprandial suppression of endogenous glucose production. Am J Physiol Endocrinol Metab. 289(6):E941-7. Abstract
2004
Wang YL, Guo W, Zang Y, Yaney GC, Vallega G, Getty-Kaushik L, Pilch P, Kandror K, Corkey BE.  2004.  Acyl coenzyme a synthetase regulation: putative role in long-chain acyl coenzyme a partitioning. Obes Res. 12(11):1781-8. Abstract
Perdomo G, Commerford SR, Richard AM, Adams SH, Corkey BE, O'Doherty RM, Brown NF.  2004.  Increased beta-oxidation in muscle cells enhances insulin-stimulated glucose metabolism and protects against fatty acid-induced insulin resistance despite intramyocellular lipid accumulation. J Biol Chem. 279(26):27177-86. Abstract
Liu YQ, Moibi JA, Leahy JL.  2004.  Chronic high glucose lowers pyruvate dehydrogenase activity in islets through enhanced production of long chain acyl-CoA: prevention of impaired glucose oxidation by enhanced pyruvate recycling through the malate-pyruvate shuttle. J Biol Chem. 279(9):7470-5. Abstract
2003
Wang T, Zang Y, Ling W, Corkey BE, Guo W.  2003.  Metabolic partitioning of endogenous fatty acid in adipocytes. Obes Res. 11(7):880-7. Abstract

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