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Recent Publications of Members of the Boston Ithaca Islet Club


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2008
Gupta D, Jetton TL, Mortensen RM, Duan SZ, Peshavaria M, Leahy JL.  2008.  In vivo and in vitro studies of a functional peroxisome proliferator-activated receptor gamma response element in the mouse pdx-1 promoter. J Biol Chem. 283(47):32462-70. Abstract
Danial NN, Walensky LD, Zhang CY, Choi CS, Fisher JK, Molina AJ, Datta SR, Pitter KL, Bird GH, Wikstrom JD, Deeney JT, Robertson K, Morash J, Kulkarni A, Neschen S, Kim S, Greenberg ME, Corkey BE, Shirihai OS, Shulman GI, Lowell BB, Korsmeyer SJ.  2008.  Dual role of proapoptotic BAD in insulin secretion and beta cell survival. Nat Med. 14(2):144-53. Abstract
Danial NN, Walensky LD, Zhang CY, Choi CS, Fisher JK, Molina AJ, Datta SR, Pitter KL, Bird GH, Wikstrom JD, Deeney JT, Robertson K, Morash J, Kulkarni A, Neschen S, Kim S, Greenberg ME, Corkey BE, Shirihai OS, Shulman GI, Lowell BB, Korsmeyer SJ.  2008.  Dual role of proapoptotic BAD in insulin secretion and beta cell survival. Nat Med. 14(2):144-53. Abstract
2007
Nagle CA, An J, Shiota M, Torres TP, Cline GW, Liu ZX, Wang S, Catlin RL, Shulman GI, Newgard CB, Coleman RA.  2007.  Hepatic overexpression of glycerol-sn-3-phosphate acyltransferase 1 in rats causes insulin resistance. J Biol Chem. 282(20):14807-15. Abstract
Yatoh S, Akashi T, Chan PP, Kaneto H, Sharma A, Bonner-Weir S, Weir GC.  2007.  NeuroD and reaggregation induce beta-cell specific gene expression in cultured hepatocytes. Diabetes Metab Res Rev. 23(3):239-49. Abstract
Yano T, Liu Z, Donovan J, Thomas MK, Habener JF.  2007.  Stromal cell derived factor-1 (SDF-1)/CXCL12 attenuates diabetes in mice and promotes pancreatic beta-cell survival by activation of the prosurvival kinase Akt. Diabetes. 56(12):2946-57. Abstract
2006
Koh HJ, Arnolds DE, Fujii N, Tran TT, Rogers MJ, Jessen N, Li Y, Liew CW, Ho RC, Hirshman MF, Kulkarni RN, Kahn CR, Goodyear LJ.  2006.  Skeletal muscle-selective knockout of LKB1 increases insulin sensitivity, improves glucose homeostasis, and decreases TRB3. Mol Cell Biol. 26(22):8217-27. Abstract
Inada A, Nienaber C, Bonner-Weir S.  2006.  Endogenous beta-galactosidase expression in murine pancreatic islets. Diabetologia. 49(5):1120-2.
Kwan EP, Xie L, Sheu L, Nolan CJ, Prentki M, Betz A, Brose N, Gaisano HY.  2006.  Munc13-1 deficiency reduces insulin secretion and causes abnormal glucose tolerance. Diabetes. 55(5):1421-9. Abstract
Rukstalis JM, Ubeda M, Johnson MV, Habener JF.  2006.  Transcription factor snail modulates hormone expression in established endocrine pancreatic cell lines. Endocrinology. 147(6):2997-3006. Abstract
Gray JP, Davis J. W. 2, Gopinathan L, Leas TL, Nugent CA, Vanden Heuvel JP.  2006.  The ribosomal protein rpL11 associates with and inhibits the transcriptional activity of peroxisome proliferator-activated receptor-alpha. Toxicol Sci. 89(2):535-46. Abstract
2005
Hagman DK, Hays LB, Parazzoli SD, Poitout V.  2005.  Palmitate inhibits insulin gene expression by altering PDX-1 nuclear localization and reducing MafA expression in isolated rat islets of Langerhans. J Biol Chem. 280(37):32413-8. Abstract
Pino MF, Ye DZ, Linning KD, Green CD, Wicksteed B, Poitout V, Olson LK.  2005.  Elevated glucose attenuates human insulin gene promoter activity in INS-1 pancreatic beta-cells via reduced nuclear factor binding to the A5/core and Z element. Mol Endocrinol. 19(5):1343-60. Abstract
Neve B, Fernandez-Zapico ME, Ashkenazi-Katalan V, Dina C, Hamid YH, Joly E, Vaillant E, Benmezroua Y, Durand E, Bakaher N, Delannoy V, Vaxillaire M, Cook T, Dallinga-Thie GM, Jansen H, Charles MA, Clement K, Galan P, Hercberg S, Helbecque N, Charpentier G, Prentki M, Hansen T, Pedersen O, Urrutia R, Melloul D, Froguel P.  2005.  Role of transcription factor KLF11 and its diabetes-associated gene variants in pancreatic beta cell function. Proc Natl Acad Sci U S A. 102(13):4807-12. Abstract
Zhao L, Guo M, Matsuoka TA, Hagman DK, Parazzoli SD, Poitout V, Stein R.  2005.  The islet beta cell-enriched MafA activator is a key regulator of insulin gene transcription. J Biol Chem. 280(12):11887-94. Abstract
Habener JF, Kemp DM, Thomas MK.  2005.  Minireview: transcriptional regulation in pancreatic development. Endocrinology. 146(3):1025-34. Abstract
Kulkarni RN, Sreevalli Y, Baskaran K.  2005.  Allelic differences at two loci govern different mechanisms of intraflower self-pollination in self-pollinating strains of periwinkle. J Hered. 96(1):71-7. Abstract
Fukui K, Yang Q, Cao Y, Takahashi N, Hatakeyama H, Wang H, Wada J, Zhang Y, Marselli L, Nammo T, Yoneda K, Onishi M, Higashiyama S, Matsuzawa Y, Gonzalez FJ, Weir GC, Kasai H, Shimomura I, Miyagawa J, Wollheim CB, Yamagata K.  2005.  The HNF-1 target collectrin controls insulin exocytosis by SNARE complex formation. Cell Metab. 2(6):373-84. Abstract
Gragnoli C, Stanojevic V, Gorini A, Von Preussenthal GM, Thomas MK, Habener JF.  2005.  IPF-1/MODY4 gene missense mutation in an Italian family with type 2 and gestational diabetes. Metabolism. 54(8):983-8. Abstract
Iype T, Francis J, Garmey JC, Schisler JC, Nesher R, Weir GC, Becker TC, Newgard CB, Griffen SC, Mirmira RG.  2005.  Mechanism of insulin gene regulation by the pancreatic transcription factor Pdx-1: application of pre-mRNA analysis and chromatin immunoprecipitation to assess formation of functional transcriptional complexes. J Biol Chem. 280(17):16798-807. Abstract
2004
Perdomo G, Commerford SR, Richard AM, Adams SH, Corkey BE, O'Doherty RM, Brown NF.  2004.  Increased beta-oxidation in muscle cells enhances insulin-stimulated glucose metabolism and protects against fatty acid-induced insulin resistance despite intramyocellular lipid accumulation. J Biol Chem. 279(26):27177-86. Abstract

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